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Eddie Olczyk: Beating the Odds in Hockey and in Life
Par Eddie Olczyk, Perry Lefko. 2019
Eddie Olczyk had built a life and career most people could only dream of. Growing up in the suburbs of…
Chicago, he fell in love with the game of hockey during an era when most kids preferred balls to pucks. Against all odds, he played on the 1984 U.S. Olympic hockey team as a 17-year-old, and four months later he was drafted in the first round by his hometown Chicago Blackhawks. During an illustrious 16-year career, he played for and alongside some of the greatest franchises and players in history, winning a Stanley Cup with the unforgettable 1994 New York Rangers. Years later, he coached former teammate Mario Lemieux and Sidney Crosby on the Pittsburgh Penguins before transitioning into the broadcast booth, where he has become one of the most recognizable voices of the sport. He then combined his skills as an analyst with his second passion— horse racing—and became an integral part of NBC’s coverage of thoroughbreds. Away from the spotlight, Olczyk and his wife of three decades raised four adoring children. He was respected and admired by fans, friends, and peers. Life was sweet. Then, at 7:07 pm on August 4, 2017, his entire world turned upside down. In Eddie Olczyk: Beating the Odds in Hockey and in Life, one of the biggest names in American hockey has written an inspiring and entertaining memoir of his life both on and off the ice. From shooting hundreds of tennis balls at a goal in his childhood living room to the ups and downs of his improbable hockey career to rollicking stories from the booth and the backstretch, Olczyk guides readers on his journey toward his ultimate test: a battle against Stage 3 colon cancer. For years, Olczyk’s goal was to be the best husband, father, broadcaster, and handicapper he could be. Today he has a new one: to bring as much awareness and support to those fighting cancer as he possibly can. In this emotional but often hilarious autobiography, you’ll learn why the people who know Eddie Olczyk best might describe him as “tremendously tremendous.”The Road Years: A Memoir, Continued . . .
Par Rick Mercer. 2023
THE INSTANT #1 BESTSELLERRick Mercer is back—again!—with the eagerly awaited sequel to his bestselling memoirAt the end of his memoir…
Talking to Canadians, Rick Mercer was poised to make the biggest leap yet in his extraordinary career. Having overcome a serious lack of promise as a schoolboy and risen through the showbiz ranks—as an aspiring actor, star of a surprisingly successful one-man show about the Meech Lake Accord, co-founder of This Hour Has 22 Minutes, creator and star of the dark-comedy sitcom Made in Canada—he was about to tackle his biggest opportunity yet. The Road Years picks up the story at that exciting point, with the greenlighting of what would become Rick Mercer Report. Plans for the show, of course, included political satire and Rick’s patented rants. But Rick and his partner, Gerald Lunz, were also determined to do something that comedy tends to avoid as too challenging: they would emphasize the positive. Rick would travel from coast to coast to coast in search of everything that’s best about Canada, especially its people. He found a lot to celebrate, naturally, and was rewarded with a huge audience and a run of 15 seasons. The Road Years tells the inside story of that stupendous success. A time when Rick was heading to another town—or military base, sports centre, national park—to try dogsledding, chainsaw carving, and bear tagging; hang from a harness (a lot); ride the “Train of Death;” plus countless other joyous and/or reckless assignments. Added to the mix were encounters with the country’s great. Every living prime minister. Rock and roll royalty from Rush to Randy Bachman. Olympians and Paralympians. A skinny-dipping Bob Rae. And Jann Arden, of course, who gets a chapter to herself. Along the way he even found the time to visit several countries in Africa and co-found and champion the charity Spread the Net, which has gone on to protect the lives of millions. Join the celebration, and revive a wealth of happy memories, with what is Rick Mercer’s funniest, most fascinating book yet.Inside a Thug's Heart
Par Angela Ardis. 2004
An intimate and revealing window into one of modern culture&’s most iconic figures, this twentieth-anniversary re-release of Inside a Thug&’s…
Heart celebrates the gifted and impassioned yet vulnerable and uncertain human behind the legend of Tupac Shakur. In 1995, one year before Tupac Shakur was shot dead in Las Vegas, he was jailed for two months inside New York City&’s notorious Rikers Island. While there, he received a letter from a stranger—Angela Ardis, acting on a casual bet with her friends. She included her photo and phone number . . . and soon found herself answering a call from Tupac himself. Remarkably, their near-daily contact grew into a complex kinship of souls that neither could define—and touched both in unexpected ways. Alive in letters and original poems—some available nowhere else—Tupac&’s ever-relevant heart beats within these pages. Playful, sensual, and serious, he gives insightful observations on music, prison, and life&’s uncertainties—and his dreams for a future that would soon be tragically cut short. In this moving, one-of-a-kind tribute, generations of fans can experience a profound connection to the mind and unbroken spirit of a passionate, unpredictable musical icon.Macrolides as Immunomodulatory Agents (Progress in Inflammation Research #92)
Par Bruce K. Rubin, Masaharu Shinkai. 2024
For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are…
not related to their antimicrobial properties. These immunomodulatory properties, best described for treating inflammatory airway diseases, protect the lung and the host and improve clinical status. This book summarizes our current knowledge regarding proposed mechanisms for these properties, established clinical results, and what the future may hold with emphasis on novel clinical applications and the fascinating development of non-antimicrobial macrolides with preserved and enhanced immunomodulatory properties.Breast Cancer Research and Treatment: Innovative Concepts (Cancer Treatment and Research #188)
Par Ouissam Al Jarroudi, Khalid El Bairi, Giuseppe Curigliano. 2023
This book focuses on innovative treatment options for breast cancer, including surgery, radiotherapy, systemic therapy and of course immunotherapy that…
is changing outcomes in some aggressive breast cancer histotypes. Subsequent chapters also address the ongoing emerging research in the screening, diagnostics, and management of all subtypes of breast cancers. All current landscapes and future perspectives in each molecular subtype: luminal, HER2-positive, and triple-negative breast cancers are discussed within the different chapters.Breast cancer is still the most common cancer and cause of cancer deaths among women worldwide. The improvement of breast cancer outcome appears to be strictly related to the validation of precise biomarkers that enable us to better select personalized approaches in breast cancer management.The closing chapters deal with the challenges of conducting research in the era of precision medicine for cancer. The book is edited and authored by leading experts in this field and will be of interest for clinicians and scientists alike.Medicinal Plants and Antimicrobial Therapies
Par Vinay Kumar, Varsha Shriram, Abhijit Dey. 2024
This book serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the…
use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR. Use of metabolomics in understanding and targeting AMR mechanisms and identifying potent phyto-therapeutics has been discussed as well. The book is a valuable read for both experienced and younger researchers working in the field of AMR and related fields in biomedicine, pharmacy, and clinical research.Univentricular Congenital Heart Defects and the Fontan Circulation: Practical Manual for Patient Management
Par Paul Clift, Konstantinos Dimopoulos, Annalisa Angelini. 2023
This book provides a concise, practically applicable guide to the management of patients born with a univentricular heart defect. It…
describes the anatomy and epidemiology of the univentricular heart, while guidance is provided on how to manage both fetal and neonatal patients with this defect, as well as those in later childhood and adulthood. The utilization of the Fontan operation for patients with a univentricular heart is described in detail. Management of early and late Fontan failure is also discussed, and the pregnant patient is also described, enabling the reader to develop a deep understanding of how to manage these patients in their daily practice. Univentricular Congenital Heart Defects: Practical Manual for Patient Management comprehensively reviews the management of univentricular heart defects and the use of Fontan-type surgery. It is a valuable resource for the experienced practitioner seeking a manual on the latest available techniques and for trainees who want to develop a thorough understanding of how to manage patients with these congenital heart defects.Handbook of Cerebrovascular Disease and Neurointerventional Technique (Contemporary Medical Imaging)
Par Mark R. Harrigan, John P. Deveikis. 2023
This fourth edition offers a practical guide to endovascular treatment of cerebrovascular disease and provides a comprehensive reference for the…
related neurovascular anatomy and the various disorders that affect the vascular system. Chapters cover fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriateBuilding on the previous edition, the text is presented similarly in style and scope to emphasize accessibility and ease of reading. All chapters are fully updated to include more recent data, and obsolete products and techniques are replaced with the most current technology. Some key updates include:A greater emphasis on the use of radial artery access for the discussed endovascular techniques.The associations of COVID-19 with ischemic stroke and the implications of providing care for cerebrovascular patients during a pandemic.An extensive update to the acute ischemic stroke chapter with new references and format to more closely follow the format of other chapters in that section.Expansion of the pediatric sections of disease chapters, including discussions of genetic associations with disease. This is an ideal guide for clinicians and trainees in neurology, neurosurgery and neuroradiology, as well as practicing clinicians in related fields caring for patients with cerebrovascular disease.Blockchain in Healthcare: Analysis, Design and Implementation (Future of Business and Finance)
Par Chang Lu, Mohan Tanniru. 2023
This books brings readers a holistic understanding of blockchain adoption in healthcare by not only considering the technical fundamentals of…
use cases, but also the regulatory, informational and organizational challenges and solutions. The book also provides frameworks and toolkits to manage the entire life cycle of adoption, including analysing the environment and feasibility, application design from a user-centred perspective, and implementation strategies that would overcome organizational and informational barriers. Specific issues addressed include but are not limited to: How to analyse the value propositions in healthcare and which distributed actors should be engaged to fulfil these propositions? What policies and practices need to be reviewed to ensure security and privacy of the information shared? How to design blockchain systems that seamlessly integrate with other stakeholder applications, while only the needed information is in the distributed architecture? How can blockchain implementation be managed from governance and risk mitigation perspectives, especially when multiple actors are involved?By reading this book, blockchain enthusiasts, health informatics professionals and healthcare executives will be better prepared to leverage the transformative potential of blockchain for healthcare.Medical Decision Making
Par Harold C. Sox, Michael C. Higgins, Douglas K. Owens, Gillian Sanders Schmidler. 2024
MEDICAL DECISION MAKING Detailed resource showing how to best make medical decisions while incorporating clinical practice guidelines and decision support…
systems Sir William Osler, a legendary physician of an earlier era, once said, “Medicine is a science of uncertainty and an art of probability.” In Osler’s day, and now, decisions about treatment often cannot wait until the diagnosis is certain. Medical Decision Making is about how to make the best possible decision given that uncertainty. The book shows how to tailor decisions under uncertainty to achieve the best outcome based on published evidence, features of a patient’s illness, and the patient’s preferences. Medical Decision Making describes a powerful framework for helping clinicians and their patients reach decisions that lead to outcomes that the patient prefers. That framework contains the key principles of patient-centered decision-making in clinical practice. Since the first edition of Medical Decision Making in 1988, the authors have focused on explaining key concepts and illustrating them with clinical examples. For the Third Edition, every chapter has been revised and updated. Written by four distinguished and highly qualified authors, Medical Decision Making includes information on: How to consider the possible causes of a patient’s illness and decide on the probability of the most important diagnoses. How to measure the accuracy of a diagnostic test. How to help patients express their concerns about the risks that they face and how an illness may affect their lives. How to describe uncertainty about how an illness may change over time. How to construct and analyze decision trees. How to identify the threshold for doing a test or starting treatment How to apply these concepts to the design of practice guidelines and medical policy making. Medical Decision Making is a valuable resource for clinicians, medical trainees, and students of decision analysis who wish to fully understand and apply the principles of decision making to clinical practice.ACSM's Resources for the Group Exercise Instructor
Par American College of Sports Medicine. 2023
ACSM’s Resources for the Group Exercise Instructor, 2nd Edition, equips fitness professionals with the knowledge and the skills needed to…
effectively lead group exercise in gyms, studios, recreational facilities, and clubs. An essential resource for undergraduate exercise science programs, students in pre-professional programs, and those independently prepping for the ACSM-GEI certification, this engaging, accessible text reflects the authoritative expertise of the American College of Sports Medicine (ACSM) and delivers complete preparation for becoming an ACSM Certified Group Exercise Instructor. The extensively revised and reorganized 2nd Edition streamlines learning and aligns content to the domains of the ACSM Certified Group Exercise Instructor Exam, boosting exam confidence and delivering step-by-step guidance to ensure success in professional practice.Celebrating 25 years of The Sopranos: The executive producer of The White Lotus shares how he got his start in…
film and television production on &“the greatest TV show of all time&” (Rolling Stone)An inside look at the film industry for fans, students, and aspiring professionals — featuring a foreword by Golden Globe and Emmy Award winning creator of The White Lotus, Mike WhiteThis page-turning account of starting at the lowest rung on the production ladder among enormously famous & outrageously demanding people will be devoured for its insights, gossip, humor, & storytelling. Married and with a child, the author takes unpaid gigs to get a foot in the door, and eventually ends up working on all seasons of The Sopranos, often named the best TV show ever.The show's setting and its creator's insistence on accuracy placed the native New Jersey author in the right place at the right time to become part of television history, and to witness the effects of sudden fame and acclaim on the show's principal players.Includes many stories about guest stars like Steve Buscemi, Peter Bogdanovich, and Lauren Bacall, as well as the beloved cast, including new tales of James Gandolfini, who Kamine first meets after David Chase casts him as the Dean of Admissions in the classic first season "College" episode. Later, after he&’s been promoted, Kamine gets the calls from Gandolfini when he's hungover, or still drunk, and might or might not make it to the shoot that day. One night, Kamine tries to prevent Gandolfini from taking a swim in the ocean after they've been drinking all night, telling him it could be dangerous but Jim doesn't listen.Woven in is a personal story of home life and strife, achievement and frustration, anxiety and accomplishment. The book's epilogue brings readers up to the moment as the author, after many more years as an anonymous everyman, eventually enjoys outsize professional success as executive producer of the HBO hit series created by Mike White, The White Lotus.Toxicology of Fishes
Par Kristine L. Willett, Neelakanteswar Aluru. 2024
This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half…
of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book: Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress. Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity. Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways. Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.The Future of Alzheimer's: Finding Inspiration & Hope Through Expert Insight
Par Sharon Ricardi. 2023
A collection of informative and inspirational thoughts of many of the nation&’s leaders in research, medicine, education, senior care and…
advocacy around the subject of Alzheimer&’s disease.The Future of Alzheimer's features candid views from experts on how they respond today to someone on the difficult journey of Alzheimer&’s and what they believe is the future hope for a cure.More than 20 experts in the field of Alzheimer's research or caretakers are asked two key questions:What advice would you give to the loved ones of someone who is newly diagnosed?Do you think there will be a cure, and if so, when?Their answers help provide context and hope for patients, caretakers and loved ones looking for answers by providing helpful insights on the disease and what's to come.Alzheimer's prevalence in the US makes it the 6th leading cause of death, killing more than half a million people, mainly seniors, every year and experts believe this number will only grow. The Future of Alzheimer's seeks to make this and other forms of dementia less of the devastating diagnosis it is now for all of those people.An evidence-based guide for doctors diagnosing, testing, and treating children with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep infections).In…
the early 1990s, a group of researchers at the National Institute of Mental Health began collecting data on children who had developed neuropsychiatric disorders (OCD and tics) following infections. They found evidence that antineuronal antibodies had developed in some of these children which attacked the basal ganglia region of the brain. MRI and PET scans in these children demonstrated inflammatory changes in the basal ganglia as well. In 1997, the researchers published the first article to describe this syndrome that they named PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep infections). In PANDAS, an autoimmune attack on the brain occurs following a Strep infection. PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) is a broader term that also includes cases following exposure to other infections, toxins, and even stress. Clinicians treating children with PANS and PANDAS have found that antibiotics targeted at the offending organisms, steroids, and IVIG results in marked improvement and occasionally complete remission of the neuropsychiatric symptoms. Disturbing symptoms consistent with many DSM-5 psychiatric disorders manifest in patients with PANS and PANDAS—yet we know that there is a biologic basis for the changes in these children. As a result, these disorders require us, as physicians, to view mental illness in an entirely new way. Resistance to this change in paradigm has made PANS and PANDAS difficult for clinicians to diagnose, unbearable for parents to endure, and controversial for scholars to accept. As such, there is no recognized standard of care. We have written this work in an effort to change that. This is a textbook by physicians for physicians. It was written to bring back some of the art of medicine to physicians caring for a group of children and families who really need it. PANS and PANDAS are complex disorders that demand a rich, multifaceted response with novel treatment approaches. The material in this book is assembled from the peer-reviewed medical literature, in combination with over thirty years of clinical experience caring for the sickest patients, both in and out of the hospital. Here you will find conclusive evidence for the existence and pathophysiology of PANS and PANDAS, alongside testing and treatment interventions the author has successfully used in his own practice with hundreds of children. The book concludes with rich appendices including commonly used labs, doses of medications and supplements, a sample flare protocol, extensive support for parents, sample IVIG orders, and much more. We hope this resource allows you, the physician, to help these suffering families heal.Cancer screening has been carried out for six decades – however, there are many unsolved problems: how to estimate key parameters…
involved in screenings, such as sensitivity, the time duration in the preclinical state (i.e., sojourn time), and time duration in the disease-free state; how to estimate the distribution of lead time, the diagnosis time advanced by screening; how to evaluate the long-term outcomes of screening, including the probability of overdiagnosis among the screen-detected; when to schedule the first exam based on one’s current age and risk tolerance; and when to schedule the upcoming exam based on one’s screening history, age, and risk tolerance. These problems need proper probability models and statistical methods in order to be dealt with. Features: This book gives a concise account of the analysis of cancer screening data, using probability models and statistical methods. Real data sets are provided so that cancer researchers and statisticians can apply the methods in the learning process. It develops statistical methods in the commonly used disease progressive model. It provides solutions to practical problems and introduces open problems. It provides a framework for the most recent developments based on the author’s research. The book is primarily aimed at researchers and practitioners from biostatistics and cancer research. Readers should have the prerequisite knowledge of calculus, probability, and statistical inference. The book could be used as a one-semester textbook on the topic of cancer screening methodology for a graduate-level course.Actinomycetes in Marine and Extreme Environments: Unexhausted Sources for Microbial Biotechnology
Par D. İpek Kurtböke. 2021
The discovery and development of antibiotics has been one of the most significant advances in medicine. In a golden era…
lasting from the 1940s to the late 1960s, antibiotic research provided mankind with a wide range of structurally diverse and effective agents for the treatment of microbial infections. Since then, actinomycetes, most notably members of the genus Streptomyces, have uninterruptedly proved to be a particularly rich source of antibiotics and other therapeutic and biotechnologically important compounds. This book brings together expert actinomycetologists to communicate the importance of finding novel antibiotic producing actinomycetes in extreme and marine environments in the light of molecular advances.The Boys and Me: My Life in the Country Music Supergroup Sawyer Brown
Par Mark Miller. 2024
The Boys and Me is the behind-the-scenes, untold story of front man and lead singer Mark Miller and his band—country…
music icons Sawyer Brown!Before The Voice and American Idol, there was Star Search with Ed McMahon. In the first season, an eclectic and charismatic country-rock band called Sawyer Brown appeared on the show, taking America by storm. From ignored underdogs in Nashville to overnight rock stars from LA to New York, they swept the competition and won. Since 1984, &“the boys&” legendary live shows, along with their relentless drive to stay true to themselves, have captivated faithful fans around the world. As front man and lead singer of the band, Mark Miller&’s rise to fame wasn&’t exactly the path he envisioned for himself. After losing his father, Mark was raised by his mom whose solid faith and strong work ethic helped guide and shape him and his brother, Frank. With his sights set on playing pro basketball, Mark never dreamed of becoming an entertainer, especially considering he was terrified to stand on a stage. But God had a different plan. Now, forty years later, Sawyer Brown has eighteen studio albums to their name, multiple No. 1 singles, fifty-plus songs charting on the Billboard Hot Country Songs, and legendary award-winning videos. And they have no plans of stopping any time soon. The band&’s longevity is a testament to their strong songwriting, high-energy performances, and hard work. This is the behind-the-scenes, untold story of Mark Miller and &“the boys&”—country music icons Sawyer Brown!Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and…
radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.The Politics of Potential: Global Health and Gendered Futures in South Africa (Medical Anthropology)
Par Michelle Pentecost. 2024
The first one thousand days of human life, or the period between conception and age two, is one of the…
most pivotal periods of human development. Optimizing nutrition during this time not only prevents childhood malnutrition but also determines future health and potential. The Politics of Potential examines early life interventions in the first one thousand days of life in South Africa, drawing on fieldwork from international conferences, government offices, health-care facilities, and the everyday lives of fifteen women and their families in Cape Town. Michelle Pentecost explores various aspects of a politics of potential, a term that underlines the first one thousand days concept and its effects on clinical care and the lives of childbearing women in South Africa. Why was the First One Thousand Days project so readily adopted by South Africa and many other countries? Pentecost not only explores this question but also discusses the science of intergenerational transmissions of health, disease, and human capital and how this constitutes new forms of intergenerational responsibility. The women who are the target of first one thousdand days interventions are cast as both vulnerable and responsible for the health of future generations, such that, despite its history, intergenerational responsibility in South Africa remains entrenched in powerfully gendered and racialized ways.