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Transesophageal Echocardiography in Pediatric Congenital Cardiac Surgery and Catheter Intervention
Par Shen-Kou Tsai, Jou-Kou Wang, Shyh-Jye Chen. 2023
This book reviews the history and evolution of intraoperative transesophageal echocardiography (TEE) as applied in various pediatric congenital heart surgeries, catheter intervention procedures…
and hybrid surgeries. The development of the pediatric TEE is described, including safety and efficacy data in infants and neonates. Practical insights of the use of TEE in cardiac surgery and catheter intervention are highlighted through actual case presentations with images and illustrations. Topics covered include TEE monitoring from pre-procedural planning, real-time assist during the surgery, confirmation of the intended results, as well as identification of residual lesions that require further surgical correction. This book will be a valuable resource for practitioners working in the field of pediatric congenital heart diseases surgery and interventional procedures where TEE plays a vital role.Glutathione (Oxidative Stress and Disease #1)
Par Leopold Flohé. 2019
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The…
book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discoveryQuantification, Validation and Uncertainty in Analytical Sciences: An Analyst's Companion
Par Max Feinberg, Serge Rudaz. 2024
Quantification, Validation and Uncertainty in Analytical Sciences Companion guide explaining all processes in measuring uncertainty in quantitative analytical results Quantification,…
Validation and Uncertainty in Analytical Sciences provides basic and expert knowledge by building on the sequence of operations starting from the quantification in analytical sciences by defining the analyte and linking it to the calibration function. Proposing a comprehensive approach to MU (Measurement Uncertainty) estimation, it empowers the reader to apply Method Accuracy Profile (MAP) efficiently as a statistical tool in measuring uncertainty. The text elucidates several examples and template worksheets explaining the theoretical aspects of the procedure and includes novel method validation procedures that can accurately estimate the data obtained in measurements. It also enables the reader to provide practical insights to improve decision making by accurately evaluating and comparing different analytical methods. Brings together an interdisciplinary approach with statistical tools and algorithms applied in analytical chemistry and written by two international experts with long-standing experience in the field of Analytical measurements and Uncertainty, Quantification, Validation and Uncertainty in Analytical Sciences includes information on: The know-how of methods in an analytical laboratory, effective usage of a spurious measurement and methods to estimate errors. Quantification, calibration, precision, trueness, MAP addons, estimating MU for analytical sciences, and uncertainty functionsEmploying measurement uncertainty, sampling uncertainty, quantification limits, and sample conformity assessmentDecision making, uncertainty and standard addition method, and accuracy profile for method comparison Quantification, Validation and Uncertainty in Analytical Sciences is an ideal resource for every individual quantifying or studying analytes. With several chapters dedicated to MU’s practical use in decision making demonstrating its advantages, the book is primarily intended for professional analysts, although researchers and students will also find it of interest.Orthopaedic Knowledge Update®: Sports Medicine 6 brings together the most relevant literature and the latest research from the past 5…
years. More than 150 top-notch contributors collaborated on this succinct review of pertinent advances in sports medicine. Find brand-new content on hip instability and microinstability, return-to-play criteria following anterior cruciate ligament injury, exercise-induced bronchorestriction, development of emergency action plans, and imaging of the foot and ankle.Langman's Medical Embryology
Par T. W. Sadler. 2024
Concise, clearly written, and vibrantly illustrated, Langman’s Medical Embryology, 15th Edition, makes complex embryology concepts approachable to help you build…
the clinical understanding essential to your success in medical practice, nursing, or other health professions. Hundreds of full-color illustrations clarify the stages of embryonic development with rich detail, and engaging learning features, clinical examples, and online review questions ready you for the challenges ahead on your exams and in clinical practice.The little-known stories of the people responsible for what we know today as modern medical ethics.In Making Modern Medical Ethics,…
Robert Baker tells the counter history of the birth of bioethics, bringing to the fore the stories of the dissenters and whistleblowers who challenged the establishment. Drawing on his earlier work on moral revolutions and the history of medical ethics, Robert Baker traces the history of modern medical ethics and its bioethical turn to the moral insurrections incited by the many unsung dissenters and whistleblowers: African American civil rights leaders, Jewish Americans harboring Holocaust memories, feminists, women, and Anglo-American physicians and healthcare professionals who were veterans of the World Wars, the Cold War, and the Vietnam War.The standard narrative for bioethics typically emphasizes the morally disruptive medical technologies of the latter part of the twentieth century, such as the dialysis machine, the electroencephalograph, and the ventilator, as they created the need to reconsider traditional notions of medical ethics. Baker, however, tells a fresh narrative, one that has historically been neglected (e.g., the story of the medical veterans who founded an international medical organization to rescue medicine and biomedical research from the scandal of Nazi medicine), and also reveals the penalties that moral change agents paid (e.g., the stubborn bureaucrat who was demoted for her insistence on requiring and enforcing research subjects&’ informed consent). Analyzing major statements of modern medical ethics from the 1946–1947 Nuremberg Doctors Trials and Nuremberg Code to A Patient&’s Bill of Rights, Making Modern Medical Ethics is a winning history of just how respect and autonomy for patients and research subjects came to be codified.Breaking Through Depression: A Guide to the Next Generation of Promising Research and Revolutionary New Treatments
Par Philip William Gold. 2023
&“A thorough, up-to-date, and upbeat introduction to current scientific thinking about mood disorders and their treatment. An important resource for…
patients and their families—and for anyone curious about progress in psychiatric research."―Peter D. Kramer, Listening to ProzacThis inspiring exploration of the recent advances in depression research and treatment shares new methods that offer promising paths to wellness. Breaking Through Depression explores how the anatomy of the brain and the biochemistry of nerve impulses play a major role in how we view ourselves and the world. Drawing from his long-term research, Dr. Philip W. Gold makes the case for depression arising at the intersection of genetic vulnerability with stressful, disturbing life experiences that get encoded in our emotional memory. Breaking Through Depression will delve into the interplay between our anatomy and our lived experiences as the key to understanding why there are such individual differences in how we make connections with others, deal with adversity, or recover from trauma. More importantly, Dr. Gold reveals the latest breakthroughs that can heal people struggling with depression, including: The FDA has fast-tracked Psilocybin and Ketamine as anti-depressant treatments, which cause immediate improvement in depressive symptoms. Low-energy lasers have been developed that can stimulate these areas directly and painlessly to relieve symptoms in treatment-resistant patients suffering from major depression. Scientists are developing genetically &‘thumbprinted' antidepressants that can be individually tailored to match a person's DNA increasing their effectiveness. Inflammation in the body and the brain is a prominent component of depressive illness, to the point that anti-inflammatory agents are useful in the treatment of depression. Incredible progress with gene therapy including a treatment overcoming the BDNF gene mutation that interferes with resiliency, promotes vulnerability to depression, and inhibits the capacity of antidepressants to work effectively. These are just a few of the fascinating new developments explored in Breaking Through Depression and the many reasons for hope that Dr. Gold shares in this groundbreaking book.Well at Work: Creating Wellbeing in any Workspace
Par Esther M. Sternberg. 2023
LONGLISTED FOR THE 2023 OWL AWARDS Full of science-backed tips on how to design any workspace for physical and emotional…
wellbeing, &“Well at Work helps us thrive wherever we work.&” (Arianna Huffington) Whether you work in a traditional office or a corner of your bedroom, staying well at work need not be a luxury. But wellness at work isn&’t just about staying physically healthy; it&’s also about reducing stress and improving mood, focus, energy, and productivity.Well at Work reveals how to optimize our workspaces for wellbeing across the seven domains of integrative health: stress and resilience, movement, sleep, relationships, environment, nutrition, and spirituality, and even the air we breathe. You&’ll learn: How the environment you work in all day can affect your sleep at night Optimal lighting and noise levels for reducing stress and improving focus How to adjust temperature and humidity to stay alert and protect against infection Why open-plan offices can keep you more active The myriad benefits of access to nature (and how to bring nature indoors) Office layouts that foster social interactions but not distraction Foods to enhance cognitive performance And more Along the way, you&’ll meet the scientists and doctors, designers and architects, and building science professionals who are striving to make workplaces more conducive to wellbeing. And you&’ll glimpse into the future of the workplace, where artificial intelligence and the metaverse will help us create environments that respond to our individual needs. Above all, you&’ll come away with a menu of simple, &“innovative, and often overlooked&” (Dr. Richard Carmona) steps anyone can take to be—and stay—well at work.Radiotheranostics - A Primer for Medical Physicists I: Physics, Chemistry, Biology and Clinical Applications (ISSN)
Par Cari Borrás, Michael G. Stabin. 2024
This book covers scientific, clinical, and educational aspects of radiotheranostics in cancer control. Setting the framework, the first volume defines…
radiotheranostics and describes the history of radionuclide therapy and theranostics, and the biology of cancer. It examines the clinical applications of unconjugated radionuclides, such as ¹³¹I and ²²³Ra, and of radionuclide-conjugated cancer-specific vectors: peptides, small molecules, antibodies, and nanoparticles; introduces clinical trials and drug development; and reviews epidemiological studies and the adverse effects of radionuclide therapy – both radiation injuries and chemical toxicity. It presents the chemistry and physics of radionuclide production, discusses radioactivity measurements and traceability, and addresses important instrumentation aspects: calibration, quantitative imaging, and quality control. Volume I concludes with guidance on the education, training, and competence of a radiotheranostic multidisciplinary team and summarizes the principal physics characteristics of theranostics today – including many to be expanded in the second volume – while offering a glimpse into tomorrow. This volume provides the foundations for the more advanced second volume, which explores dosimetric and radiation safety, aiming to empower medical physicists and demonstrate to the cancer community how to improve cancer control and yield increased patient survival times.It will be a valuable reference for medical and health physicists with basic knowledge of nuclear medicine.Key Features• Provides a comprehensive introduction to the topic, presenting readers with thorough treatment in a cohesive two-volume book.• Presents a rigorous approach while remaining accessible to students and trainees in the field.• Contains consistent and extensive references to allow readers to delve deeper into the subject.The Journal of Clinical Ethics, volume 35 number 1 (Spring 2024)
Par The Journal of Clinical Ethics. 2024
This is volume 35 issue 1 of The Journal of Clinical Ethics. The Journal of Clinical Ethics is uniquely focused…
on ethical issues that arise in direct patient care, in the clinic and at the bedside, as well as with related issues and challenges in the broader practice of medicine, healthcare delivery, and best practices. The journal engages with issues of primary concern to physicians and patients—and families—and all members of the clinical team, including allied professionals in ethics consultation, as well as scholars and professionals in diverse disciplines and care-related practices: philosophy, law, theology, public and health policy, nursing, and organizational ethics.Cardiac Cowboys: The Heroic Invention of Heart Surgery
Par Gerald Imber. 2024
Cardiac Cowboys is the dramatic story of five deeply flawed geniuses who together—and in competition with each other—invented open-heart surgery…
against all conventional medical wisdom and saved millions of lives.A decade after World War II, there was still no such thing as open-heart surgery, and yet half a million Americans were dying from heart disease every year. One in a hundred children would suffer and die from congenital heart disease as well, and doctors did little other than predict their deaths. After the first daring operation in 1954 and through the next three decades, five heroic surgeons braved the scorn of their peers, withstood fierce desperation, and faced possible death in order to devise procedures that would save overwhelming numbers of those doomed children and provide hope for a new life to all manner of heart-failing individuals. Devising and mastering heart transplants and bypass surgery, they invented artificial heart valves, the lifesaving pacemaker, and worked toward the holy grail of an artificial heart as their private and professional lives imploded. The story of the Cardiac Cowboys, their outsized personalities, and often self-destructive behavior is a saga more thrilling and exhilarating than fiction.Regenerative Health: Discover Your Metabolic Type and Renew Your Liver for Life
Par Kristin Kirkpatrick, Ibrahim Hanouneh. 2024
The authors of Skinny Liver offer a new look at liver disease through four types of conditions and deliver practical…
plans for liver health. Your liver plays a key role in your health, affecting chronic inflammation, heart health, mental health, cognitive health, and metabolic health (including type 2 diabetes). Yet most people aren&’t aware of its power—and are unknowingly sabotaging their liver health. Medical understanding has evolved to reveal that metabolic health is the best indicator of fatty liver risk, meaning that treating fatty liver disease is less about losing weight (and the unhealthy diet culture that accompanies it) and more about adopting smart lifestyle habits to reduce your risk. Based on the most up-to-date research, Regenerative Health introduces the four metabolic profiles—the Preventer, the Fine-Tuner, the Re-calibrator, and the Regenerator–and an easy assessment. Once you determine your type, you&’ll follow easy steps to customize your Regenerative Health eating and lifestyle plan. With practical tips on nutrition, exercise, and wellness; meal suggestions; recipes; and recommended snacks, Regenerative Health will help you treat your current liver issues and also help you prevent more from developing. Whether you already have a diagnosis or simply want to be feel as good as you can, experts Kristin Kirkpatrick and Ibrahim Hanouneh give you the knowledge and the tools to take charge of your health.Physician Leader: How Exam Room Experience Drives Leadership Excellence
Par Hanah Polotsky, Lisa Williams. 2024
Physicians are often asked to lead healthcare teams, departments, divisions, practices, and hospitals. Though many of them are experts in…
their fields, they are rarely prepared or educated in business management and leadership. Based on the authors’ interviews with many physician and non-physician executives and leaders, medical training contributes little to leadership skills. Many physicians leave medical training with a command-and-control leadership style that later has to be unlearned to succeed in a team-based healthcare environment. This book will help physician leaders to shed derailers and authoritarian leadership tendencies picked up in years of medical training. It is intended for (1) physicians who are transitioning to healthcare leadership roles, (2) senior-level physician and non-physician leaders as a coaching model to develop their physician leader direct reports, and (3) administrative leaders who are partnering with physician leaders. Both authors progressed from mid-level leadership roles to the C-suite, one as a physician leader and one as an administrative leader. As such, they have leveraged their operational excellence expertise to design the Iterative Leadership Model that includes the leader’s mindset, Leadership Strategies, and a coaching framework: GUIDES (Gather, Understand, Identify, Design, Execute, and Self-Reflect) that is based on the scientific method, PDSA (Plan, Do, Study, Act), A3 thinking, and the SOAP (Subjective, Objective, Assessment, and Plan) note format. The authors masterfully integrate personal reflections, coaching examples, illustrative fictional vignettes, and GUIDES exercises to support leaders in the self-development and self-improvement of seven critical Leadership Attributes: strategic thinking, effective communication, coaching, team-building, change management, continuous learning, and problem-solving.Down Syndrome Screening: A Practical Guide
Par Abhijit Kamat. 2023
The book elucidates a practical method for prenatal screening and detecting Down syndrome in a simple and easy-to-understand language. It…
provides thorough knowledge on the subject, and each chapter covers a specific topic, making this book an essential quick-reference guide for every antenatal clinic. The book contains chapters on maternal serum screening, noninvasive prenatal testing (NIPT), invasive testing with amniocentesis and CVS, and screening in twins. It also includes advanced chapters on multi-step screening protocols, uncommon aneuploidies, screening for preeclampsia, and open neural tube defects for clinicians interested in fetal medicine. Down syndrome is the most typical genetic condition affecting over 5 million individuals globally. Rapid advances in the medical field make it possible to identify most of these babies before birth. Hence, aneuploidy screening is now offered to pregnant women worldwide. The book aims to help obstetricians and gynecologists diagnose Down syndrome and other aneuploidies in pregnancy, avoid unnecessary testing, and remain safely within medico-legal boundaries. It is also helpful for fetal medicine students. The book helps the readers address challenging clinical scenarios and confusing test results.Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines (AAPS Introductions in the Pharmaceutical Sciences #8)
Par Jenny Ka Wing Lam, Philip Chi Lip Kwok. 2023
Therapeutic macromolecules and biologics have gained increasing importance in the last decade. Pulmonary and intranasal delivery of these therapeutic modalities,…
which have poor oral bioavailability, could constitute an attractive, non-invasive alternative to parenteral delivery. They can be considered for either topical use for treating diseases affecting the airways or for systemic use for treating a variety of other diseases. Therefore, this book is a readable, thoughtful, and useful guide on the latest research developments and the best options that people involved with pulmonary and intranasal route of administration and biologically active agents can bring to their practices. Furthermore, it explores the underlying scientific rationale for the strategies applied to overcome drug delivery challenges and provides insights to inspire further research in this growing area.Fatal to Fearless: 12 Steps to Beating Cancer in a Broken Medical System
Par Kathy Giusti. 2024
An empowering, soul-baring personal account and guide from a two-time cancer survivor and healthcare disrupter that shows anyone how to…
deal with a frightening medical diagnosis in America today, providing the knowledge necessary to take ownership of personal wellbeing and maximize the chances for survival.More than twenty-five years ago, Kathryn Giusti was diagnosed with multiple myeloma at age thirty-seven and given three years to live. With a young child, a happy marriage, and a successful career, Giusti had too much to live for. An “impatient patient,” she overcame her fear and got to work, learning to advocate for her own care. This book is the result of all she’s learned about how to get the best outcome from America’s opaque and sometimes impossible-to-navigate healthcare system.Fatal to Fearless tells the story of how Giusti took on the system and turned it to her advantage not once but twice when she was diagnosed with breast cancer a few years ago. It is a crash course in surviving a grim diagnosis, organized around twelve simple steps, with practical tips for everything from how to build your healthcare team and learning which online sources to trust, to understanding the science and identifying which tests to ask for in the new genomic era and how to access the treatments and studies that could save your life.At its center is a gripping personal story that reveals difficult, yet honest truths about illness, family, friendship, marriage, and the business of medicine. Giusti lays bare her soul as she walks you through the steps for handling any diagnosis and includes insights from medicine’s top insiders on the frontlines of physical and emotional healing and care.Sick people deserve a fighting chance. Giusti’s mission to democratize medicine—and healthcare—has never been more imperative, or more urgent. Hopeful, wise, and packed with hard-won knowledge, this book gives you the concrete tools and inspiration to fear less and live more.Kokumi Substance as an Enhancer of Koku: Biochemistry, Physiology, and Food Science
Par Motonaka Kuroda. 2024
This book provides the basic concepts and latest findings on kokumi substances. It covers not only the topics related to…
food chemistry, but also the biochemical and physiological mechanisms of the perception of kokumi substances. Food palatability is determined by many factors, including taste, aroma, texture, color, physiological condition, and circumstances. The attribute called “koku” is used in Japan to express delicious foods. The definition of koku attribute was previously proposed to be caused by the sensation of richness, body, lingering (continuity), and mouthfulness in terms of taste, aroma, and texture. Kokumi substance is one of the taste-related koku enhancers and is defined as a substance that enhances complexity, richness (body), and lastingness (continuity), although it has no taste itself at the dose. The topics in this book cover physiological studies, including the receptor mechanism, taste nerve recording, and human brain responses using functional MRI. It also discusses the sensory characteristics of kokumi substances when added to foods and the effect of kokumi substances on the satiety. The intended readers are university students, researchers and technologists in food science, food chemistry, nutritional sciences, taste physiology, and neuroscience. Non-expert readers interested in food palatability and the deliciousness of foods may also find this book useful.Immersive Technology and Experiences: Implications for Business and Society
Par Githa S. Heggde, Santosh Kumar Patra, Rasananda Panda. 2024
This book provides a comprehensive overview of the role of immersive technology with multiple sectoral perspectives, such as entertainment, education,…
health care, and more. It covers a detailed analysis of the latest trends and developments in the field. It encompasses practical insights on using immersive technology effectively through industry expert chapters, case studies, and real-world examples that demonstrate how immersive technology is being used in different industries. Chapters in this book are from academicians and industry professionals to create a fine balance of knowledge and practice perspective of today’s immersive technology. It is written in accessible language that is easy for non-experts to understand. It focuses on the future of immersive technology, exploring its potential impact on society and the economy. It provides insights into the challenges and opportunities that lie ahead and offers predictions on how immersive technology will continue to evolve in the years to come. It is a valuable resource for anyone learning more about immersive technology.Robotic Surgery of Colon and Rectum (Updates in Surgery)
Par Graziano Ceccarelli, Andrea Coratti. 2024
This is an open access book. Colorectal surgery is one of the most performed procedures in dedicated colorectal and general surgery…
units worldwide. In the last two decades, the minimally invasive laparoscopic approach has become very popular worldwide, attracting great interest among patients (lower risk of infection, less pain, and faster recovery) and demonstrating excellent oncological results. Technology is improving rapidly, offering revolutionary innovations, particularly with the advent of robotic surgery, which offers important advantages over laparoscopy for both surgeons and patients: improved ergonomics, wristed instruments, and a better vision. These advantages may be particularly useful for more complex and challenging situations (complete mesocolic excision, low rectal cancer, one-stage treatment of colorectal and liver metastases, etc.), translating into potential improved surgical and oncological results. Although several books have been published on the subject, the great interest in robotic surgery makes it mandatory, in our opinion, to have a general update in view of the latest technical innovations and the results of the most relevant and recent literature. The book is divided into chapters dealing with the different colorectal segments with their robotic surgical operations and specific technical variants. The new frontiers of benign and emergency colorectal diseases are also considered, as well as the new robotic platforms recently introduced in the healthcare market. Some of them, such as the da Vinci SP single port device, may represent a revolutionary approach for this surgery. Training and cost aspects were also considered.Thyroid Surgery (Updates in Surgery)
Par Mario Testini, Angela Gurrado. 2024
This open access book on thyroid surgery has been authored by an international team of contributors who present a comprehensive…
understanding of both benign and malignant thyroid disorders. It also outlines an interdisciplinary approach to their surgical management that reflects the latest changes in surgical techniques. The book reviews the most up-to-date literature available on thyroid surgery and presents it in a concise manner for use in clinical practice. For each thyroid disorder, the book covers etiology, clinical manifestations, diagnostic and localization procedures, as well as surgical and non-surgical treatment options. The operating techniques and postoperative management are explained in detail, while the benefits, risks, controversial issues, and cost-effectiveness of each approach are reviewed. To aid in the understanding of complex information, the book features drawings and photographs. Written in an easy-to-understand style, the book includes tables and diagrams that highlight best practices and current guidelines, as well as self-assessment material at the end of each section. It serves as an ideal resource for all levels of surgical experience, from a practical reference for endocrine surgeons to a perfect companion for students and residents.