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Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)
Par Noriyuki Koibuchi, Paul Yen. 2016
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone…
during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. Testosterone: From Basic to Clinical Aspects
Par Alexandre Hohl. 2017
Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use.…
This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men’s health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).Post-transcriptional Mechanisms in Endocrine Regulation
Par Aaron Goldstrohm, K. Menon. 2016
This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of…
hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.Deeper Than Money: Ditch Money Shame, Build Wealth, and Feel Confident AF
Par Chloe Elise. 2023
A guide for women to find financial confidence, say goodbye to guilt, and finally get ahead with money without sacrificing…
what they care about, from money expert, podcaster, and CEO Chloe Elise.This is not your average finance book. Like most people these days, Elise went to college not only with student loans, but also completely clueless as to how debt even worked. Instead of abiding by restrictive, guilt-filled advice, she set off on a new debt-payoff journey where she made the rules. Fast-forward eighteen months, and not only did she become completely debt-free, paying off more than $36,000 of debt, but she did it while traveling and enjoying life in her twenties. And now she&’s sharing how you can do it, too. In Deeper Than Money, Elise demystifies finance for anyone who feels stuck in cycles of guilt around spending. Part practical guide to finance and part motivational kick in the butt to set yourself up for success, this book is all about showing how to live your life, love your finances, and make money matter less. It&’ll have you ready to talk about money at brunch with your friends, and finally allow you to get ahead with money—without skipping the mimosa. Deeper Than Money will help you level up not only your finances, but also your life. Because in order to enjoy the wealth you&’re building, you also need to enjoy the life you&’re living.The Power of Flexing: How to Use Small Daily Experiments to Create Big Life-Changing Growth
Par Susan Ashford. 2021
A leadership and learning expert shows you how to change your behavior, develop soft skills, and achieve personal and professional…
growth through a series of small experiments she calls “Flexing.” A personnel shift at your organization puts you into a leadership role you don't feel prepared for. Your boss tells you that you seem aloof and unapproachable in client meetings. You need to win the support of the members of a local community group for a project you feel passionate about.Addressing these diverse issues depends on improving your soft skills—such as time management, team building, communication and listening, creative thinking, and problem-solving. But this isn’t as easy as it may seem.Sue Ashford, the chair of the Management and Organizations group at the Ross School of Business, has the solution. In this timely book, she introduces Flexing—a technique individuals, teams, and entire organizations can use to learn, grow, and develop their skills and knowledge with every new project, work assignment, and problem. Flexing empowers you to embrace any challenge and adapt to any change, yielding practical, valuable takeaways that ensure growth.Flexing helps you move ahead when you’re confronted with a new challenge, or simply want to develop a vital skill. It’s a journey that begins with setting a flex goal—stating explicitly what you want to learn and how you want to grow. Once that flex goal is set, you then begin to run experiments, solicit feedback from peers or colleagues, and monitor and tweak your progress on the way to achieving your goal. Flexing can be tailored to each person, allowing you to reflect on your own experiences and incorporate the lessons you learn in the next project you tackle. It’s a growth mindset that will help you become the best version of yourself.Flexing also works with teams and organizations. Ashford teaches small groups and large how to implement flexing to ensure their members are ready for new challenges. With more people moving to remote working full-time and developing new ways of collaborating in teams, this warm and practical guide will help every professional and any organization on the journey to greater effectiveness.A researcher and consultant burrows deep inside the heads of one modern two-career couple to examine how each partner processes…
the workday—revealing how a more nuanced understanding of the brain can allow us to better organize, prioritize, recall, and sort our daily lives.Emily and Paul are the parents of two young children, and professionals with different careers. Emily is the newly promoted vice president of marketing at a large corporation; Paul works from home or from clients' offices as an independent IT consultant. Their days are filled with a bewildering blizzard of emails, phone calls, more emails, meetings, projects, proposals, and plans. Just staying ahead of the storm has become a seemingly insurmountable task.In Your Brain at Work, Dr. David Rock goes inside Emily and Paul's brains to see how they function as each attempts to sort, prioritize, organize, and act on the vast quantities of information they receive in one typical day. Dr. Rock is an expert on how the brain functions in a work setting. By analyzing what is going on in their heads, he offers solutions Emily and Paul (and all of us) can use to survive and thrive in today's hyperbusy work environment—and still feel energized and accomplished at the end of the day.In Your Brain at Work, Dr. Rock explores issues such as:why our brains feel so taxed, and how to maximize our mental resourceswhy it's so hard to focus, and how to better manage distractionshow to maximize the chance of finding insights to solve seemingly insurmountable problemshow to keep your cool in any situation, so that you can make the best decisions possiblehow to collaborate more effectively with otherswhy providing feedback is so difficult, and how to make it easierhow to be more effective at changing other people's behaviorand much more.Andrology: Male Reproductive Health and Dysfunction
Par Eberhard Nieschlag, Hermann Behre, Susan Nieschlag, Sabine Kliesch. 2023
The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central…
topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of andrology and male reproductive medicine.Becoming a Master Communicator: Balancing New School Technology with Ol' School Simplicity
Par Renée Marino. 2022
Becoming a Master Communicator is a practical and exciting guidebook from the communication coach who was the female lead actress…
of Clint Eastwood’s Jersey Boys, that will transform readers into a confident, authentic communicator in their personal and professional relationships.Ignite a Shift: Engaging Minds, Guiding Emotions and Driving Behavior
Par Stephen McGarvey. 2022
Career Magic: How to Stay on Track to Achieve a Stellar Career
Par Lee Cockerell. 2016
Career Magic depicts the lessons Lee Cockerell learned during his magical and successful career with Hilton, Marriott and Disney and…
teaches how motivated individuals can achieve their dreams—no matter the obstacles!Chronic Hope: Raising a Child with Chronic Illness with Grace, Courage, and Love
Par Bonnie O’Neil. 2021
Chronic Hope helps parents of children living with chronic disease gain practical wisdom for managing the emotional stress of raising…
a chronically ill child, so they can navigate these challenges with grace, courage, and love.Live Your Truth: Start Your Journey to Freedom and Healing
Par Colleen Gallagher. 2017
From being diagnosed with cancer at age 14, Colleen saw many people leave this life without ever truly living, Live…
Your Truth empowers people to find the truth, fall in love with life, and intoxicate the world with love.The Art of Feminine Negotiation: How to Get What You Want from the Boardroom to the Bedroom
Par Cindy Watson. 2023
The Biggest Little Book About Hope
Par Kathryn Goetzke. 2022
With hopelessness at unprecedented levels around the world, and a key predictor of suicide, violence, self-harm, and addiction, it is…
essential to teach the ‘how’ of hope. The Biggest Little Book About Hope teaches the hope skills necessary for anyone looking to integrate hope into their everyday lives.Fit Financial Approach: The Candid Truth About Being Fit in BOTH Health & Wealth
Par Mike Broker. 2021
The Elevated Leader: Level Up Your Leadership Through Vertical Development
Par Ryan Gottfredson. 2023
The Elevated Leader is a cutting-edge leadership development book that explains how vertical development can guide leaders to effectively navigate…
the rising change, pressure, ambiguity, and complexity they are increasingly facing, while having a positive and uplifting influence on the world around them.Coach, Run, Win is one of the most complete and significant contributions to cross country training methods for a high…
school program and is as valuable an aid to the coach as the stopwatch itself.Power Up Power Down: How to Reclaim Control and Make Every Situation a Win-Win
Par Gail Rudolph. 2022
When Screams Become Whispers: One Man’s Inspiring Victory Over Bipolar Disorder
Par Bob Krulish, Alee Anderson. 2021
A real, raw telling of a man’s lifelong struggle with bipolar disorder, When Screams Become Whispers offers a better understanding…
of the disease, the extent of its reach, and the dire need for widely available treatment options.