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The greatest experiment ever performed on women: exploding the estrogen myth
Par Barbara Seaman. 2003
Cofounder of the National Women's Health Network explains the controversy surrounding the use of hormone replacement drugs--primarily estrogen--for birth control,…
menopause, and postmenopause. Traces the history of their development, marketing, and use in the twentieth century. Suggests that women are at risk from doctors who view menopause as a disease. 2003Le diabète et ses complications: prévention, prise en charge, traitement
Par Gérard Pacaud. 1995
"L'auteur décrit clairement les mécanismes métaboliques qui conduisent au diabète. Il donne de précieux conseils sur l'hygiène de vie et…
l'utilisation des médicaments et précise ce que les diabétiques peuvent attendre de la recherche ou des médecines alternatives."Following the Good River: The Life and Times of Wa'xaid
Par Briony Penn. 2020
Based on recorded interviews and journal entries this major biography of Cecil Paul (Wa’xaid) is a resounding and timely saga…
featuring the trials, tribulations, endurance, forgiveness, and survival of one of North America’s more prominent Indigenous leaders. Born in 1931 in the Kitlope, Cecil Paul, also known by his Xenaksiala name, Wa’xaid, is one of the last fluent speakers of his people’s language. At age ten he was placed in a residential school run by the United Church of Canada at Port Alberni where he was abused. After three decades of prolonged alcohol abuse, he returned to the Kitlope where his healing journey began. He has worked tirelessly to protect the Kitlope, described as the largest intact temperate rainforest watershed in the world. Now in his late 80s, he resides on his ancestors’ traditional territory.Following upon the success of Wa'xaid's own book of personal essays, Stories from the Magic Canoe, Briony Penn's major biography of this remarkable individual will serve as a timely reminder of the state of British Columbia's Indigenous community, the environmental and political strife still facing many Indigenous communities, and the philosophical and personal journey of a remarkable man.Wa'xaid passed away at the age of 90 on December 3, 2020.Life in Two Worlds: A Coach's Journey from the Reserve to the NHL and Back
Par Ted Nolan. 2023
In 1997 Ted Nolan won the Jack Adams Award for best coach in the NHL. But he wouldn’t work in…
pro hockey again for almost a decade. What happened?Growing up on a First Nation reserve, young Ted Nolan built his own backyard hockey rink and wore skates many sizes too big. But poverty wasn’t his biggest challenge. Playing the game meant spending his life in two worlds: one in which he was loved and accepted and one where he was often told he didn’t belong.Ted proved he had what it took, joining the Detroit Red Wings in 1978. But when his on-ice career ended, he discovered his true passion wasn’t playing; it was coaching. First with the Soo Greyhounds and then with the Buffalo Sabres, Ted produced astonishing results. After his initial year as head coach with the Sabres, the club was being called the "hardest working team in professional sports." By his second, they had won their first Northeast Division title in sixteen years.Yet, the Sabres failed to re-sign their much-loved, award-winning coach.Life in Two Worlds chronicles those controversial years in Buffalo—and recounts how being shut out from the NHL left Ted frustrated, angry, and so vulnerable he almost destroyed his own life. It also tells of Ted’s inspiring recovery and his eventual return to a job he loved. But Life in Two Worlds is more than a story of succeeding against the odds. It’s an exploration of how a beloved sport can harbour subtle but devastating racism, of how a person can find purpose when opportunity and choice are stripped away, and of how focusing on what really matters can bring two worlds together.The energy paradox: what to do when your get-up-and-go has got up and gone (Plant paradox #6)
Par Steven R Gundry. 2021
"In his bestselling books, |The Plant Paradox| and |The Longevity Paradox|, Dr. Steven R. Gundry offered game-changing perspectives on our…
wellbeing. In |The Energy Paradox|, Dr. Gundry expands upon his previous discussions of gut, microbiome, and mitochondrial health, linking immune malfunction to the mental and physical symptoms of fatigue-including exhaustion, brain fog, depression, anxiety, and low metabolism. As Dr. Gundry explains, feeling tired, moody, and zapped of energy is not normal, no matter your workload or age. Fatigue is an SOS flare from the body, one that is intended to alert us that something is wrong. In his clinical work, Dr. Gundry has found that his patients who complain of feeling sick and tired all the time almost always have something in common: the inflammation markers of a leaky gut. In |The Energy Paradox|, Dr. Gundry will offer readers the information and tools necessary to quiet the autoimmune battle raging within-a battle that depletes precious energy reserves, leaving you drained and prone to mood disorders and weight gain. With new guidelines on how to increase mitochondrial energy production and nourish the microbiome; 30 new Plant Paradox-approved recipes; and lists of energy-boosting foods to consume and energy-depleting foods to avoid, |The Energy Paradox| will help readers take back their lives, giving them the energy they need to feel, look, and be their best." -- Provided by publisherReclaiming Diné history: the legacies of Navajo Chief Manuelito and Juanita
Par Jennifer Denetdale. 2007
In this groundbreaking book, the first Navajo to earn a doctorate in history seeks to rewrite Navajo history. Reared on…
the Navajo Nation in New Mexico and Arizona, Jennifer Nez Denetdale is the great-great-great-granddaughter of a well-known Navajo chief, Manuelito (1816-1894), and his nearly unknown wife, Juanita (1845-1910). Stimulated in part by seeing photographs of these ancestors, she began to explore her family history as a way of examining broader issues in Navajo historiography. Here she presents a thought-provoking examination of the construction of the history of the Navajo people (Diné, in the Navajo language) that underlines the dichotomy between Navajo and non-Navajo perspectives on the Diné past. Reclaiming Diné History has two primary objectives. First, Denetdale interrogates histories that privilege Manuelito and marginalize Juanita in order to demonstrate some of the ways that writing about the Diné has been biased by non-Navajo views of assimilation and gender. Second, she reveals how Navajo narratives, including oral histories and stories kept by matrilineal clans, serve as vehicles to convey Navajo beliefs and values. By scrutinizing stories about Juanita, she both underscores the centrality of women's roles in Navajo society and illustrates how oral tradition has been used to organize social units, connect Navajos to the land, and interpret the past. She argues that these same stories, read with an awareness of Navajo creation narratives, reveal previously unrecognized Navajo perspectives on the past. And she contends that a similarly culture-sensitive re-viewing of the Diné can lead to the production of a Navajo-centered history. AdultCrazy Horse and Custer: the parallel lives of two American warriors
Par Stephen E Ambrose. 1996
Tracking the Caribou Queen: Memoir of a Settler Girlhood
Par Margaret Macpherson. 2022
In this challenging memoir about her formative years in Yellowknife in the '60s and '70s, author Margaret Macpherson lays bare…
her own white privilege, her multitude of unexamined microaggressions, and how her childhood was shaped by the colonialism and systemic racism that continues today. Macpherson's father, first a principal and later a federal government administrator, oversaw education in the NWT, including the high school Margaret attended with its attached hostel: a residential facility mostly housing Indigenous children.Ringing with damning and painful truths, this bittersweet telling invites white readers to examine their own personal histories in order to begin to right relations with the Indigenous Peoples on whose land they live. Tracking the Caribou Queen is beautifully crafted to a purpose: poetic language and narrative threads dissect the trope that persisted through her girlhood, that of the Caribou Queen, a woman who seemed to embody extreme and contradictory stereotypes of Indigeneity. Here, Macpherson is not striving for a tidy ideal of "reconciliation"; what she is working towards is much messier, more complex and ambivalent and, ultimately, more equitable.Unbroken: My Fight for Survival, Hope, and Justice for Indigenous Women and Girls
Par Angela Sterritt. 2023
"A remarkable life story.... Angela Sterritt is a formidable storyteller and a passionate advocate." (Cherie Dimaline, author of The Marrow…
Thieves) "Sterritt's story is living proof of how courageous Indigenous women are." (Tanya Talaga, author of Seven Fallen Feathers and All Our Relations) In her memoir, Angela Sterritt shares her story from navigating life on the streets to becoming an award-winning journalist. As a teenager, she wrote in her notebook to survive. Now, she reports on cases of missing and murdered Indigenous women in Canada, showing how colonialism and racism create a society where Indigenous people are devalued. Unbroken is a story about courage and strength against all odds.Clinical Metabolomics Applications in Genetic Diseases
Par Anas M. Abdel Rahman. 2023
This book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This…
comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.The Type 2 Diabetes Revolution: A Cookbook and Complete Guide to Managing Type 2 Diabetes
Par Diana Licalzi, Jose Tejero. 2023
Discover how you can reverse the root cause of type 2 diabetes with this innovative, easy-to-follow guide, which includes a…
4-week meal plan and over 100 delicious, high-fiber, plant-based recipes.If you have prediabetes or type 2 diabetes, this approach can help you achieve non-diabetic blood sugar within weeks. The simple lifestyle changes outlined in this book focus on the reversal of insulin resistance—the root cause of high blood sugar.Developed by a registered dietitian and exercise physiologist, The Type 2 Diabetes Revolution uses a revolutionary, science-based program to provide:Daily meal plans for 4 weeks, designed to minimize your time in the kitchen Simple grocery shopping lists for every week of the meal plan and tips for meal prep100+ high-fiber, plant-based recipes that keep your blood sugar balanced Advice on how to create a balanced diet that includes whole, plant-based foods and meat, if desiredTips for grocery shopping and how to read nutritional labels Guidance on stocking your pantry and knowing which foods to always have on hand Useful lessons and tips on how nutrition, exercise, sleep, and stress impact your diabetes healthStart reversing the root cause of type 2 diabetes, eliminate or reduce your need for medication, and lower your blood sugar with The Type 2 Diabetes Revolution.Spanish translation of this book will be available in Spring 2024. ISBN: 9781958803622A practical, empowering guide to managing and reversing prediabetes through diet and exercise, from a registered dietitian. Affecting 96 million…
Americans, prediabetes often develops into full-blown type 2 diabetes, one of the leading causes of death in the United States. Increasingly diagnosed by doctors, prediabetes is a condition in which blood sugar levels are elevated, but not yet high enough to be labeled diabetes. While diabetes cannot be cured, prediabetes can be reversed, so it is critical to take action at an early stage. In straightforward, jargon-free language, The Prediabetes Diet Plan explains insulin resistance (the underlying cause of prediabetes and type 2 diabetes) and offers a comprehensive strategy of diet and lifestyle change, which has been proven more effective than medication. With sections on meal planning, grocery shopping, dining out, supplements, and exercise, this book empowers you to make healthier everyday choices that can effect real change on your insulin levels and overall well-being.Drawing upon oral and documentary evidence, this volume explores the lives of noteworthy Mi’kmaw individuals whose thoughts, actions, and aspirations…
impacted the history of the Northeast but whose activities were too often relegated to the shadows of history. The book highlights Mi’kmaw leaders who played major roles in guiding the history of the region between 1680 and 1980. It sheds light on their community and emigration policies, organizational and negotiating skills, diplomatic endeavours, and stewardship of land and resources. Contributors to the volume range from seasoned scholars with years of research in the field to Mi’kmaw students whose interest in their history will prove inspirational. Offering important new insights, the book re-centres Indigenous nationhood to alter the way we understand the field itself. The book also provides a lengthy index so that information may be retrieved and used in future research. Muiwlanej kikamaqki – Honouring Our Ancestors will engage the interest of Indigenous and non-Indigenous readers alike, engender pride in Mi’kmaw leadership legacies, and encourage Mi’kmaw youth and others to probe more deeply into the history of the Northeast.Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients
Par Fady Hannah-Shmouni. 2023
This book is composed of 13 informative chapters written by world-renowned healthcare providers and researchers in the fields of endocrinology,…
pharmacy, radiology, infertility, pediatrics, internal medicine, psychology and genetics. From topics covering psychosocial impacts to pharmacokinetic and homecare resources, the intent of this book is to provide guiding principles for a safe and informative transition of care for pediatric and adolescent patients with various familial endocrine cancer syndromes that are transitioning from pediatric to adult health care. It provides an in-depth exploration of the diagnostic and therapeutic strategies, survivorship navigation intervention, patient, caregiver and primary care provider challenges, and multidisciplinary care plans for conditions such as MEN1, MEN2 and other familial and genetic endocrine neoplasias.Familial Endocrine Cancer Syndromes: Navigating the Transition of Care for Pediatric and Adolescent Patients is a much-needed resource, as the literature currently lacks a comprehensive publication to facilitate pediatric patients’ transition to adult clinics and resources following endocrine cancer diagnosis and treatment.Environment Impact on Reproductive Health: A Translational Approach
Par Roberto Marci. 2023
This open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses…
the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.Sex and Gender Effects in Pharmacology (Handbook of Experimental Pharmacology #282)
Par Stella E. Tsirka, Maricedes Acosta-Martinez. 2023
Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease…
state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.Hydro Saline Metabolism: Epidemiology, Genetics, Pathophysiology, Diagnosis and Treatment (Endocrinology)
Par Massimiliano Caprio, Fabio Luiz Fernandes-Rosa. 2023
This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and…
pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also features an update on the clinical management of these diseases, including new diagnostic and therapeutic tools. Written by a combination of recognized and emerging experts in the field, this book is intended as a major reference work, not only for endocrinologists and nephrologists, but also for pediatricians, neonatologists, cardiologists, and emergency medicine and intensive care specialists, who can be faced with the management of endocrine diseases responsible of salt and water imbalance. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic, peer-review publishing process.Diabetes and Me: Living a Healthy and Empowered Life in the Face of Diabetes
Par David Novak, Wendy Louise Novak. 2023
"Children with diabetes can live full, happy, productive lives. I hope my story can stand as proof of that fact."Diagnosed…
with type 1 diabetes at age seven, Wendy Louise Novak had to create her own path in a world defined by stigma, struggle, and hope.With little public awareness of her condition, Wendy's only role model was her fiercely independent father, who grew up in an era when diabetes meant a difficult, and often short, life. He taught her to "follow the rules" and stay self-reliant. That sense of independence carried Wendy through college to a successful career, globetrotting excitement, and a whirlwind romance with her husband, David.Wendy built a loving family as she navigated the highs and lows of a condition that was still widely misunderstood. Despite tough times, she learned to balance following the rules with following her passions, saying, "I never wanted to be the kind of person who stayed home and worried about whether or not I could take it, and so I didn't."Today, Wendy is the face of the Wendy Novak Diabetes Institute, which supports groundbreaking clinical services, education, and research to ensure young people with diabetes can thrive. In this honest but uplifting account of a life well lived, Wendy shares what she has learned, including practical tips for managing diabetes.With a foreword by the author's husband, businessman and philanthropist David Novak, Diabetes and Me shows patients and families that a diagnosis doesn't define your life."There are always ways to experience the joys in life, no matter what it throws at you."Thyroid Hormone Disruption and Neurodevelopment (Contemporary Clinical Neuroscience)
Par Noriyuki Koibuchi, Paul Yen. 2016
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone…
during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. Testosterone: From Basic to Clinical Aspects
Par Alexandre Hohl. 2017
Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use.…
This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men’s health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).